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What helps the ionized drug molecules to pass through the cell membrane passively?

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What helps the ionized drug molecules to pass through the cell membrane passively?

(a) Different pH

(b) Polar group

(c) Large lipophilic group

(d) Hydration

I have been asked this question in unit test.

My question comes from Drugs Absorption topic in portion Absorption of Drugs of Drug Biotechnology

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The correct choice is (c) Large lipophilic group

Easiest explanation: Ionised drugs if attached with a large lipophilic group in their structure. This helps them in getting absorbed passively e.g. morphine derivatives.

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