Question

What is the equation to find out the apparent volume of distribution?

(a) Amount of drug in the body/plasma drug concentration

(b) Plasma drug concentration/amount of drug in the body

(c) 1 / plasma drug concentration

(d) 1 / Amount of drug in the body

The question was asked during a job interview.

The query is from One & Two Compartment Open Model in division Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology

Answer 1

The correct choice is (a) Amount of drug in the body/plasma drug concentration

Explanation: The apparent volume of distribution Vd is given by Amount of drug in the body (X) / plasma drug concentration (C). Vd is expressed in liters.