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Which drugs bind to HSA easily?

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in Drug Biotechnology by (138k points)
Which drugs bind to HSA easily?

(a) Cationic drug

(b) Anionic drug

(c) Lipophilic drug

(d) Neutral drug

I had been asked this question in an interview for internship.

Query is from Factors Affecting Protein Drug Binding in division Protein Binding of Drugs of Drug Biotechnology

1 Answer

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Right choice is (b) Anionic drug

To elaborate: Anionic or acidic drugs bind to HSA easily, for example, penicillin and sulphonamides. Cationic or basic drugs bind easily to alpha 1 acid glycoprotein, for example, imipramine and alprenolol. Neutral and unionized drugs bind to lipoproteins. Lipophilic drugs localize more into adipose tissue.

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