Question

In the equation X= Vd C, what does X stands for?

(a) Amount of drug in the blood

(b) Amount of drug in plasma

(c) Amount of drug in the tablet

(d) Amount of drug in the body

This question was addressed to me during an internship interview.

Query is from Factors Affecting Protein Drug Binding in section Protein Binding of Drugs of Drug Biotechnology

Answer 1

The correct answer is (d) Amount of drug in the body

To elaborate: The relationship between tissue-drug binding and apparent volume of distribution can be established as Vd = amount of drug in the body (X)/ Plasma drug concentration (C).