Question

Which drugs easily bind to adipose tissue?

(a) Cationic drug

(b) Anionic drug

(c) Lipophilic drug

(d) Neutral drug

This question was posed to me in an interview for job.

My enquiry is from Factors Affecting Protein Drug Binding in section Protein Binding of Drugs of Drug Biotechnology

Answer 1

The correct answer is (c) Lipophilic drug

To elaborate: Anionic or acidic drugs bind to HSA easily. Cationic or basic drugs bind easily to alpha 1 acid glycoprotein. Neutral and unionized drugs bind to lipoproteins. Lipophilic drugs localize more into adipose tissue. Since lipophilic drugs are lipid loving they can easily get deposited on the adipose tissue.