Question

Displacement interactions are significant in the case of drugs which are more than 95% bound.

(a) True

(b) False

I got this question by my college professor while I was bunking the class.

Query is from Factors Affecting Protein Drug Binding topic in portion Protein Binding of Drugs of Drug Biotechnology

Answer 1

Correct choice is (a) True

Easy explanation: A displacement of 1% and 99% bound drug results in doubling of the free drug concentration i.e. a 100% rise. For a drug which is bound to 99% and a displacement of 1% results in only a 10% rise in freed rug concentration which may be insignificant clinically.