Question

The extent of drug-protein binding can change with both changes in protein and drug concentration.

(a) True

(b) False

The question was posed to me by my college professor while I was bunking the class.

This intriguing question originated from Factors Affecting Protein Drug Binding topic in section Protein Binding of Drugs of Drug Biotechnology

Answer 1

The correct answer is (a) True

For explanation: The concentration of drug that binds to HSA do not have much influence on HA, since any concentration of drug in less than the concentration of HSA. The therapeutic concentration of lidocaine can saturate AAG with which it binds as the concentration of AAG is much less in comparison to that of HSA in blood.