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How do you calculate the rate of excretion by kidneys?

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How do you calculate the rate of excretion by kidneys?

(a) Rate of filtration – the rate of secretion – Rate of absorption

(b) Rate of filtration + rate of secretion – Rate of absorption

(c) Rate of filtration + rate of secretion + Rate of absorption

(d) Rate of filtration – the rate of secretion + Rate of absorption

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This intriguing question originated from Drugs Excretion in chapter Prodrugs & Excretion of Drugs of Drug Biotechnology

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Correct choice is (b) Rate of filtration + rate of secretion – Rate of absorption

Explanation: The rate of excretion through the kidneys is given by Rate of filtration + rate of secretion – Rate of absorption. Absorption is the reabsorption of the drug particles back to the system thus it gets minus from the filtrated amount and secreted amount.

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