Question

Which is the predominant form of cyclooxygenase enzyme?

(a) COX 1

(b) COX 2

(c) COX 3

(d) COX 4

The question was asked in an international level competition.

Question is from Drug Addiction and Abuse topic in chapter Local & General Anesthetics, Opioid Analgesics, Drug Addiction and Drug Abuse of Drug Biotechnology

Answer 1

Correct answer is (a) COX 1

For explanation: The key enzyme in the cyclooxygenase pathway is the enzyme cyclooxygenase (COX). There are two forms of cyclooxygenase, COX1 (the predominant form) and COX2. NSAIDs inhibit prostaglandin and thromboxane synthesis, they are potent inhibitors of cyclooxygenase and eliminate all prostaglandins and thromboxanes in every cell they reach.