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Which of the following are semi-synthetic opiates?

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Which of the following are semi-synthetic opiates?

(a) Codeine

(b) Oxycodone

(c) Fentanyl

(d) Endomorphins

I have been asked this question in final exam.

I want to ask this question from Opioid Analgesics topic in section Local & General Anesthetics, Opioid Analgesics, Drug Addiction and Drug Abuse of Drug Biotechnology

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Correct answer is (b) Oxycodone

Best explanation: Semi-synthetic opiates are created from natural opiates such as hydromorphone, oxycodone, and diacetylmorphine. These are mad by simple modification of the existing natural chemical structure of the compound making it more potent, less toxic etc. Natural opiates are alkaloid contained in the resin of the opium poppy including morphine and codeine. Fully synthetic opioids are such as fentanyl, methadone, etc.

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