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Which of the following promotes edema?

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Which of the following promotes edema?

(a) Histamine

(b) Serotonin

(c) Bradykinin

(d) Prostaglandins

The question was posed to me in a job interview.

My doubt is from Drug Addiction and Abuse topic in section Local & General Anesthetics, Opioid Analgesics, Drug Addiction and Drug Abuse of Drug Biotechnology

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The correct answer is (d) Prostaglandins

To explain I would say: Prostaglandins promote edema and leukocyte infiltration and increase vascular permeability, enhance pain producing properties of bradykinin. Bradykinin major contributors to symptoms of inflammation. Leukotrienes increase vascular permeability and iincrease mobilization of endogenous mediators of inflammation.

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