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What are the characteristics of floating or buoyant capsule systems?

(a) Release the drug along the entire length of GIT

(b) Granule drug with hydro gel

(c) Release only at a specific drug

(d) Use of high or low density pellets

The question was posed to me by my college professor while I was bunking the class.

This intriguing question originated from Biopharmaceuticals topic in section Biopharmaceuticals of Drug Biotechnology

1 Answer

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The correct choice is (b) Granule drug with hydro gel

To explain: Floating of buoyant capsules are formulated by granulating a drug with 20-80% of hydrogel. On contact with the GI fluids these tablets swells and forms a diffusible gel that lowers the density of the system allowing it to float. Or a gas filled floatation chamber can be attached to a membrane coated tablet for making it buoyant.

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