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Which of the following is untrue about the Sfold algorithm?

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Which of the following is untrue about the Sfold algorithm?

(a) It uses a unique algorithm to aid in the design of siRNA

(b) The algorithm combines thermodynamic stabilities, calculations of target accessibility, and empirical rules

(c) The website offers specialized programs for the design of siRNA, antisense RNA, trans-cleaving RNA, and mRNA-microRNA interactions

(d) The website doesn’t offer programs for the design of a general program for statistically sampling suboptimal RNA structures

This question was addressed to me in an online interview.

Enquiry is from Searching Genomes for RNA & RNA Structure Modeling Applications in chapter RNA Structure Prediction of Bioinformatics

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The correct choice is (d) The website doesn’t offer programs for the design of a general program for statistically sampling suboptimal RNA structures

Easy explanation: The algorithm uses a partition function calculation and then groups suboptimal structures by similarity. The centroid structure is the most-representative structure that is closest in similarity to all the other structures.

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