Question

What type of drug administration will have the shown compartment model?

(a) Intravenous administration

(b) Oral administration

(c) Rectal administration

(d) Sublingual administration

This question was addressed to me in class test.

Asked question is from Pharmacokinetic Models topic in section Pharmacokinetic Drug Interactions & Basic Considerations of Drug Biotechnology

Answer 1

Correct answer is (d) Sublingual administration

Easy explanation: There is an arrow entering the 1^st compartment. Thus this two-compartment model is for extravascular administration. The 2nd compartment is for the organs with poor perfusion. Ko1 is the rate constant, i.e. the first order absorption rate constant and K10 is the first order elimination rate constant. K12 and K21 is the rate constant for the absorption into the organs of the 2nd compartment and elimination from the 2nd compartment organs.