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Which one of the following factor related to protein-drug binding is not related to drug interactions with the binding site?

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Which one of the following factor related to protein-drug binding is not related to drug interactions with the binding site?

(a) Competition between the drug and the binding site

(b) Competition between drugs and normal body constituents

(c) Allosteric changes in a protein molecule

(d) Inter subject variation

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This interesting question is from Factors Affecting Protein Drug Binding topic in division Protein Binding of Drugs of Drug Biotechnology

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The correct option is (d) Inter subject variation

The explanation is: Competition between the drug and the binding site, competition between drugs and normal body constituents, allosteric changes in protein molecule these factors are related to drug interactions. Inter subject variation is a patient-related factor.

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