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Which is the major rate-limiting step in the absorption of a drug from suspension dosage?

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Which is the major rate-limiting step in the absorption of a drug from suspension dosage?

(a) Tablet disintegration to granules

(b) Granules disintegration to fine particles

(c) Fine particles dissolution

(d) Dissolution absorbed into the blood

The question was asked by my school principal while I was bunking the class.

Question is from Drugs Absorption topic in division Absorption of Drugs of Drug Biotechnology

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The correct choice is (c) Fine particles dissolution

Easy explanation: The step of drug dissolution is generally rapid due to the large surface area of the particles. Factors which are essential in drug dissolution from the suspension are particle size, polymorphism, wettability, etc.

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