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Which drug easily bind to AAG?

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Which drug easily bind to AAG?

(a) Cationic drug

(b) Anionic drug

(c) Lipophilic drug

(d) Neutral drug

I have been asked this question during an interview.

This is a very interesting question from Factors Affecting Protein Drug Binding topic in division Protein Binding of Drugs of Drug Biotechnology

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Right option is (a) Cationic drug

The explanation is: Anionic or acidic drugs bind to HSA easily. Cationic or basic drugs having negative charge can bind easily to alpha 1 acid glycoprotein, for example, imipramine and alprenolol. Neutral and unionized drugs bind to lipoproteins. Lipophilic drugs localize more into adipose tissue.

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