Question

What reasons make tissue-drug binding important for drug distribution?

(a) Increases the volume of distribution of drugs and results in localization of drug at a specific site

(b) Increases the volume of distribution of drugs

(c) Results in localization of drugs at a tissue specific site

(d) Increases in absorption from the tissue due to concentration increasing

I had been asked this question in class test.

This intriguing question originated from Tissue Binding of Drugs topic in chapter Protein Binding of Drugs of Drug Biotechnology

Answer 1

Correct choice is (a) Increases the volume of distribution of drugs and results in localization of drug at a specific site

For explanation: Tissue-drug binding is important in the distribution of drugs. This is because it increases the apparent volume of distribution of drugs in contrast to plasma protein which decreases it. Tissue-drug binding results in localization of the drug at a specific site in the body.