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Which of the following drugs accumulate in skin?

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in Drug Biotechnology by (138k points)
Which of the following drugs accumulate in skin?

(a) Acidic drugs like imipramine

(b) Basic drugs like imipramine

(c) Halogenated hydrocarbons

(d) Chloroquine

I got this question in an international level competition.

My question is taken from Tissue Binding of Drugs topic in chapter Protein Binding of Drugs of Drug Biotechnology

1 Answer

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Correct option is (d) Chloroquine

To elaborate: Skin as melanin which protects us from the harmful UV rays of the sun. Chloroquine and phenothiazines accumulate in skin by interacting with melanin.

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