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Following is the order in decreasing order of drug binding to the extravascular tissue. Which one is the correct order?

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Following is the order in decreasing order of drug binding to the extravascular tissue. Which one is the correct order?

(a) Liver > kidney > muscle  > lung

(b) Liver > muscle  > lung > kidney

(c) Liver > muscle  > kidney  > lung

(d) Liver > kidney > lung > muscle

I have been asked this question by my school principal while I was bunking the class.

This intriguing question comes from Tissue Binding of Drugs topic in portion Protein Binding of Drugs of Drug Biotechnology

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The correct option is (d) Liver > kidney > lung > muscle

Easiest explanation: Factors influencing localization of drugs are tissues lipophilicity, structure of drug, perfusion rate, pH differences etc. Drugs binding to the extracellular site has the order of binding in decreasing order liver > kidney > lung > muscle.

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