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Which of the following drugs are responsible for retinopathy?

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Which of the following drugs are responsible for retinopathy?

(a) Acidic drugs like imipramine

(b) Basic drugs like imipramine

(c) Halogenated hydrocarbons

(d) Chloroquinine

I have been asked this question during an online exam.

This interesting question is from Tissue Binding of Drugs in portion Protein Binding of Drugs of Drug Biotechnology

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Right answer is (d) Chloroquinine

For explanation I would say: Chloroquine and phenothiazines accumulate in skin by interacting with melanin.  Since our retinal pigment of eye also has melanin, binding of chloroquine and phenothiazines to it is responsible for retinopathy.

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