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Which drugs accumulate in liver?

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+1 vote
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in Drug Biotechnology by (138k points)
Which drugs accumulate in liver?

(a) Acidic drugs like imipramine

(b) Basic drugs like imipramine

(c) Halogenated hydrocarbons

(d) Chloroquinine

This question was posed to me in an interview for internship.

Origin of the question is Tissue Binding of Drugs topic in chapter Protein Binding of Drugs of Drug Biotechnology

1 Answer

+1 vote
by (1.1m points)
The correct answer is (b) Basic drugs like imipramine

To explain: Imipramine is a basic drug. Basic drug like imipramine, chlorpromazine and anti-histamines accumulate in lungs.

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