Question

What type of drug administration will have the shown compartment model?

(a) Intravenous administration

(b) Oral administration

(c) Rectal administration

(d) Extravascular administration

The question was asked during an interview for a job.

Question is taken from Pharmacokinetic Models in division Pharmacokinetic Drug Interactions & Basic Considerations of Drug Biotechnology

Answer 1

Right option is (d) Extravascular administration

Explanation: There is an arrow entering the 1^st compartment, thus this one compartment model will be for extravascular administration such as oral, rectal, vaginal, etc. The 1^st compartment is shown for the blood which will be passing through the liver, lungs, kidneys, etc.  Ko1 is the rate constant, i.e. the first order absorption rate constant and K10 is the first order elimination rate constant.